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New York, NY, and Tel Aviv, ISRAEL, March 31, 2022 (Globe NEWSWIRE) — via NewMediaWire — Todos Health-related, Ltd. (OTCQB: TOMDF), a detailed health-related diagnostics and linked alternatives company, right now announced that its vast majority-owned subsidiary 3CL Pharma, Ltd. is reporting a situation research from a patient with Long COVID who was advisable Tollovid by their health practitioner Dr. John Mabayoje, a family members medicine medical professional based in Richmond, Maryland.
Abstract:
Put up-Acute Sequelae of SARS-CoV-2 (PASC), or Long COVID, is a important community wellbeing challenge. We report a case of breakthrough PASC and its resolution pursuing a course of the 3CL protease inhibitor dietary dietary supplement Tollovid®.
SUMMARIZED Circumstance REPORT:
A 49-yr-previous feminine presented with COVID-19 indicators of lethargy, persistent good tests and lack of ability to return to work since she was discharged from the hospital soon after a small admission with COVID-19. Even though in the healthcare facility the medical doctors begun her on Typical COVID-19 protocols and discharged her 7 times afterwards with guidance to use residence oxygen until finally she felt improved. She weaned herself off of oxygen right after 7 times, but she was nevertheless not able to return to perform because of to weak point and a positive COVID-19 nasal PCR exam. She endured from minimal electrical power, extreme somnolence, straightforward fatigability, myalgia, and headaches. A series of blood exams revealed no abnormal findings. Nonetheless, she persisted in screening favourable for COVID-19 on nasal swab specimens. She took a nasopharyngeal swab COVID-19 examination each individual other week for 12 months. Throughout this time period, she consulted with two doctors who approved her acetaminophen and ibuprofen.
Immediately after a extensive critique of her record, Dr. John Mabayoje concluded that she had prolonged COVID, or what doctors refer to as write-up-acute sequelae of COVID-19 (PASC), also acknowledged as Lengthy Hauler syndrome. Dr. Mabayoje sent her a bottle of commercially out there dietary dietary supplement Tollovid that contained 60 capsules and instructed her to acquire 3 capsules every 6 several hours for 5 consecutive times. She responded to the supplement and all of her indicators had been removed in 1 week. At the conclusion of the week she analyzed destructive by PCR. She resumed do the job all over again following an absence of almost 3 months and has not expert any COVID or PASC symptoms for 4 months.
About Tollovid®
Tollovid is a nutritional nutritional supplement products designed from pure ingredients that support help and keep healthy immune function and also has powerful 3CL protease inhibition attributes based mostly on in vitro purposeful assays that present potent inhibition of 3CL protease exercise. Tollovid’s 3CL protease IC50 binding affinity is at minimum ten times as powerful as Ivermectin’s published 3CL protease IC50 binding affinity. Tollovid binds to the lively website (receptor binding domain) of the 3CL protease. Tollovid has a 5-working day dosing regimen, with 4 doses of 3 products taken each and every working day that presents maximum immune aid.
About Tollovir®
Tollovir® is a 3CL protease inhibitor and anti-cytokine therapeutic prospect for the remedy of the nidovirus subcategory of coronaviruses that features SARS-CoV-2, COVID-19, SARS-CoV-1, MERS and 229E. Tollovir is designed from all normal substances that are capable to make certain strong inhibition of the 3CL protease in vitro, as effectively as solid anti-cytokine action. Tollovir is at the moment in a Stage 2 medical trial in Israel for the treatment method of individuals hospitalized with COVID-19. Tollovir will be developed for the remedy of hospitalized COVID-19 (severe and crucial), moderate COVID-19, very long-haul COVID and likely pediatric COVID-19. Todos has licensed rights for Tollovir to T-Mobile Secure Hellas S.A. for the Greek industry.
About Todos Professional medical Ltd.
Founded in Rehovot, Israel with workplaces in New York City, Todos Healthcare Ltd. (OTCQB: TOMDF) engineers life-preserving diagnostic options for the early detection of a range of cancers. The Firm’s point out-of-the-artwork and patented Todos Biochemical Infrared Analyses (TBIA) is a proprietary cancer-screening technological innovation utilizing peripheral blood analysis that deploys deep evaluation into cancer’s affect on the immune process, on the lookout for biochemical alterations in blood mononuclear cells and plasma. Todos’ two internally made most cancers-screening checks, TMB-1 and TMB-2 have obtained a CE mark in Europe. Todos recently obtained U.S.-based healthcare diagnostics firm Provista Diagnostics, Inc. to achieve legal rights to its Alpharetta, Georgia-based CLIA/CAP qualified lab currently undertaking PCR COVID screening and Provista’s proprietary business-phase Videssa® breast cancer blood examination.
Todos is also developing blood exams for the early detection of neurodegenerative conditions, these kinds of as Alzheimer’s disorder. The Lymphocyte Proliferation Test (LymPro Test™) is a diagnostic blood examination that establishes the capacity of peripheral blood lymphocytes (PBLs) and monocytes to face up to an exogenous mitogenic stimulation that induces them to enter the cell cycle. It is believed that particular health conditions, most notably Alzheimer’s condition, are the outcome of compromised mobile machinery that leads to aberrant mobile cycle re-entry by neurons, which then sales opportunities to apoptosis. LymPro is exclusive in the use of peripheral blood lymphocytes as a surrogate for neuronal mobile operate, suggesting a widespread connection concerning PBLs and neurons in the mind.
Todos has entered into distribution agreements with firms to distribute selected novel coronavirus (COVID-19) exam kits. The agreements cover several international suppliers of PCR testing kits and linked supplies and supplies, as perfectly as antibody screening kits from numerous suppliers right after completing validation of claimed screening kits and materials in its husband or wife CLIA/CAP qualified laboratory in the United States. Also, Todos has entered into a joint enterprise with NLC Pharma to go after the growth of diagnostic tests concentrating on the 3CL protease, as effectively as 3CL protease inhibitors that target a elementary reproductive mechanism of coronaviruses.
For additional data, remember to visit https://www.todosmedical.com/.
Ahead-hunting Statements
Particular statements contained in this push release may constitute ahead-looking statements. For illustration, ahead-hunting statements are applied when talking about our predicted scientific improvement plans and clinical trials. These forward-searching statements are primarily based only on present expectations of administration, and are matter to considerable hazards and uncertainties that could induce real results to vary materially from these described in the ahead-searching statements, which include the challenges and uncertainties associated to the development, timing, value, and success of clinical trials and solution growth courses challenges or delays in getting regulatory approval or patent protection for product or service candidates competition from other biotechnology companies and our potential to acquire supplemental funding demanded to carry out our investigate, progress and commercialization pursuits. In addition, the following components, amongst other individuals, could bring about true results to differ materially from people described in the ahead-hunting statements: adjustments in technology and marketplace demands delays or obstructions in launching our medical trials alterations in laws lack of ability to well timed create and introduce new systems, products and solutions and programs absence of validation of our technological know-how as we development further more and absence of acceptance of our procedures by the scientific neighborhood lack of ability to keep or appeal to vital staff members whose understanding is vital to the enhancement of our items unforeseen scientific problems that might create with our method greater price of ultimate product than anticipated loss of market place share and pressure on pricing ensuing from the competition and laboratory results that do not translate to equally excellent effects in actual configurations, all of which could cause the true benefits or functionality to vary materially from those people contemplated in these kinds of forward-hunting statements. Other than as usually needed by law, Todos Medical does not undertake any obligation to publicly release any revisions to these forward-looking statements to reflect gatherings or situation right after the date hereof or to reflect the event of unanticipated gatherings. For a far more in-depth description of the challenges and uncertainties influencing Todos Medical, be sure to refer to its studies submitted from time to time with the U.S. Securities and Trade Fee.
Todos Corporate Contact:
Daniel Hirsch
CFO
Todos Healthcare
917-983-4229 x 104
Todos Trader Relations Call:
Eric Ribner
LifeSci Advisors
Electronic mail: [email protected]
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